一、个人基本情况

陈桂兰，博士，必赢线路检测3003研究员

二、教育工作经历

2000-2004 西华师范大学生物科学专业，理学学士

2004-2007 四川大学细胞生物学专业，理学硕士

2013-2016 四川大学遗传学专业，理学博士

2007-2024 西南医科大学，助理研究员/副研究员/研究员

2008-2009 日本德岛大学，访问学者

2011-2013 英国赫尔大学，研究助理

2024至今 必赢线路检测3003，研究员

三、研究领域

1. 新型离子通道和转运蛋白的生理、病理功能

2. 心血管、呼吸和神经系统疾病的分子病理机制

四、代表性项目

1. 国家自然科学基金面上项目 (32171106)，2022-2025，负责人

2. 国家自然科学基金青年基金项目 (31300965)， 2014-2016，负责人

五、代表性成果

1. Chen GL^#, Li JY^#, Chen X^#, Liu JW^#, Zhang Q^#, Liu JY, Wen J, Wang N, Lei M, Wei JP, Yi L, Li JJ, Ling YP, Yi HQ, Hu Z, Duan J, Zhang J, Zeng B* (2024) Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation-induced surfactant secretion. Journal of Clinical Investigation 134(5):e174508.

2. Chen GL, Zeng B, Jiang H, Daskoulidou N, Saurabh R, Chitando RJ, Xu SZ* (2023) Ca(2+) Influx through TRPC Channels Is Regulated by Homocysteine-Copper Complexes. Biomolecules 13(6):952.

3. Xu XX, Shi RX, Fu Y, Wang JL, Tong X, Zhang SQ, Wang N, Li MX, Tong Y, Wang W, He M, Liu BY, Chen GL*, Guo F* (2023) Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy. Neural Regeneration Research 18(6):1277-1285.

4. Wang N, Yang Y, Wen J, Fan XR, Li J, Xiong B, Zhang J, Zeng B, Shen JW*, Chen GL* (2022) Molecular Determinants for the High-Affinity Blockade of Human Ether-a-go-go-Related Gene K + Channel by Tolterodine. Journal of Cardiovascular Pharmacology 80(5):679-689.

5. Liu J^#, Ge Y^#, Wang N, Wen J, Wang W, Zeng B, Chen GL* (2021) A Simple and Efficient Method to Generate Gene-Knockout and Transgenic Cell Lines. DNA and Cell Biology 40(2): 239-246.

6. Duan J^#, Li J^#, Chen GL^#, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Zhou L, Liu W, Tian X, Wang J, Clapham DE, Zeng B*, Li Z*, Zhang J* (2019) Cryo-EM structure of TRPC5 at 2.8 Å resolution reveals unique and conserved structural elements essential for channel function. Science Advances 5: eaaw7935.

7. Zeng B^#*, Chen GL^#, Garcia-Vaz E^#, Bhandari S, Daskoulidou N, Berglund LM, Jiang H, Hallett T, Zhou LP, Huang L, Xu ZH, Nair V, Nelson RG, Ju W, Kretzler M, Atkin SL, Gomez MF, Xu SZ* (2017) ORAI channels are critical for receptor-mediated endocytosis of albumin. Nature Communications 8(1):1920.

8. Zeng B^#, Chen GL^#, Daskoulidou N, Xu SZ* (2014) The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels. British Journal of Pharmacology 171, 1250-1259.

9. Chen GL^#, Zeng B^#, Eastmond S, Elsenussi SE, Boa AN, Xu SZ* (2012) Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels. British Journal of Pharmacology 167, 1232-1243.